Case Studies
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An 87 year old male patient presents with a 2 cm mass in the liver. There is no known clinical history of malignancy.
Histology
A core biopsy of the liver exhibits replacement by the normal tissue by an adenocarcinoma comprised of fused glands with enlarged nuclei and prominent nucleoli.Immunophenotype
The neoplastic glands are nonreactive with antibodies to cytokeratin 7 and 20, but express prostate specific antigen and prostatic acid phosphatase.Diagnosis
Metastatic prostatic adenocarcinoma (previously unknown diagnosis) involving the liver. -
A 62 year old male presents with a right nasal mass.
Histology
Underlying the respiratory epithelium, there is a proliferation of basaloid cells which exhibit a “sieve-like” pattern, with the luminal spaces being filled with basophilic material. In addition, there is dysplasia of the overlying metaplastic epithelium.Immunophenotype/additional studies
The neoplastic cells are immunoreactive with antibodies to cytokeratin 7, p16 and p63. In-situ hybridization studies for high risk human papilloma virus is positive.Diagnosis
Human Papillomavirus-Related Carcinoma with Adenoid Cystic-like Features.