An 87 year old male patient presents with a 2 cm mass in the liver. There is no known clinical history of malignancy.
A core biopsy of the liver exhibits replacement by the normal tissue by an adenocarcinoma comprised of fused glands with enlarged nuclei and prominent nucleoli.
The neoplastic glands are nonreactive with antibodies to cytokeratin 7 and 20, but express prostate specific antigen and prostatic acid phosphatase.
Metastatic prostatic adenocarcinoma (previously unknown diagnosis) involving the liver.
A 62 year old male presents with a right nasal mass.
Underlying the respiratory epithelium, there is a proliferation of basaloid cells which exhibit a “sieve-like” pattern, with the luminal spaces being filled with basophilic material. In addition, there is dysplasia of the overlying metaplastic epithelium.
The neoplastic cells are immunoreactive with antibodies to cytokeratin 7, p16 and p63. In-situ hybridization studies for high risk human papilloma virus is positive.
Human Papillomavirus-Related Carcinoma with Adenoid Cystic-like Features.